- Project 1 - CaSR-mediated signalling in colonocytes
- Project 2 - Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer
- Project 3 - Role of the CaSR in inflammatory lung diseases
- Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
- Project 5 - Delineation of CaSR signalling in primary cells and cell lines with native receptor expression
- Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
- Project 7 - Cell-specific CaSR signaling
- Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
- Project 9 - Evaluation of CaSR-targeted drugs for the treatment of diabetes mellitus
- Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
- Project 11 - Ligand-biased G-protein activation by CaSR
- Project 12 - The role of CaSR in AD pathomechanisms
- Project 13 - In silico analysis of CaSR-ligand interaction
- Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry
Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
Host Institution: University of Florence
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Hypothesis: therapeutic solutions to sarcopenia involve activation of myogenesis. As the CaSR is expressed in myocytes, selective CaSR modulators will impact the onset of sarcopenia.
Objectives: Sarcopenia is an age-related process characterized by loss of skeletal muscle mass and function and it causes physical disability. ESRUNIFI will 1) develop an in vitro model of primary cultures of human skeletal muscle myocytes and will evaluate which proteins, including receptors, modulating signals and ion channels, are involved in myogenesis; 2) assess the role of the CaSR in differentiation of adult mesenchymal stem cells into myocytes and in myoblasts differentiated from adipose mesenchymal stem cells (hAMSCs); 3) test selective CaSR modulators for their benefits in skeletal muscle differentiation.
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