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Projects / Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
 
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  • Project 1 - CaSR-mediated signalling in colonocytes
  • Project 2 - Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer
  • Project 3 - Role of the CaSR in inflammatory lung diseases
  • Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
  • Project 5 - Delineation of CaSR signalling in primary cells and cell lines with native receptor expression
  • Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
  • Project 7 - Cell-specific CaSR signaling
  • Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
  • Project 9 - Evaluation of CaSR-targeted drugs for the treatment of diabetes mellitus
  • Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
  • Project 11 - Ligand-biased G-protein activation by CaSR
  • Project 12 - The role of CaSR in AD pathomechanisms
  • Project 13 - In silico analysis of CaSR-ligand interaction
  • Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry


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Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis

Host Institution: University of Liverpool
» Info

Hypothesis: The CaSR is a determinant of pancreatic beta-cell function and peripheral insulin action.

Objectives: ESRUL will 1) Investigate role of CaSR in beta-cell electrophysiology, and the development and maintenance of beta-cell mass, using islets harvested from Nuf mice with a gain-of-function CaSR mutation; 2) Characterise effects of CaSR on the peripheral actions of insulin in wild-type and affected Nuf mice.

 
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