Host Institution: University of Liverpool
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Hypothesis: The CaSR is a determinant of pancreatic beta-cell function and peripheral insulin action.
Objectives: ESRUL will 1) Investigate role of CaSR in beta-cell electrophysiology, and the development and maintenance of beta-cell mass, using islets harvested from Nuf mice with a gain-of-function CaSR mutation; 2) Characterise effects of CaSR on the peripheral actions of insulin in wild-type and affected Nuf mice.