- Project 1 - CaSR-mediated signalling in colonocytes
- Project 2 - Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer
- Project 3 - Role of the CaSR in inflammatory lung diseases
- Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
- Project 5 - Delineation of CaSR signalling in primary cells and cell lines with native receptor expression
- Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
- Project 7 - Cell-specific CaSR signaling
- Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
- Project 9 - Evaluation of CaSR-targeted drugs for the treatment of diabetes mellitus
- Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
- Project 11 - Ligand-biased G-protein activation by CaSR
- Project 12 - The role of CaSR in AD pathomechanisms
- Project 13 - In silico analysis of CaSR-ligand interaction
- Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry
Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
Host Institution: Fundació Sant Joan de Deu
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Hypothesis: Allosteric activators of the CaSR inhibit NB tumour growth by inducing cytodifferentiation and/or cell death and by targeting the CaSR expressed in tumour cells and/or vessels. CaSR signalling in NB cells is not dependent on the origin of the expression (native versus ectopic/transfection mediated expression).
Objectives: ESRFSJD will 1) Determine the effect of calcimimetics on NB tumour growth in vitro and in vivo; 2) Assess the molecular mechanisms responsible for the observed phenotypes: 3) Analyse ligand- and cell-type biased signalling (comparing pathways activated by calcimimetics in NB versus non-neoplastic cells; and in NB cells with ectopic versus native expression); 4) Explore the effect of calcimimetics on metastases of NB cells to the bone marrow.
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