Project 3 - Role of the CaSR in inflammatory lung diseases

Host Institution: Cardiff University
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Hypothesis: CaSR activation in the airways leads to airway hyperresponsiveness, remodeling and inflamation, which can be prevented by pharmacological ablation of the CaSR, suggesting a role for the CaSR in the pathogenesis of asthma and possibly COPD and other inflammatory lung diseases. Topically delivered calcilytics can be repurposed as anovel asthma/COPD treatment.

Objectives: ESR_CU will 1) Characterise the ability of inhaled calcilytics to ameliorate airway function in established pre-clinical models of asthma and COPD; 2) Characterise the interplay between the smooth muscle and epithelium CaSR; 3) Determine the effects of cronic administartion of topically delivered calcilytics in vivo.