- Project 1 - CaSR-mediated signalling in colonocytes
- Project 2 - Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer
- Project 3 - Role of the CaSR in inflammatory lung diseases
- Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
- Project 5 - Delineation of CaSR signalling in primary cells and cell lines with native receptor expression
- Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
- Project 7 - Cell-specific CaSR signaling
- Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
- Project 9 - Evaluation of CaSR-targeted drugs for the treatment of diabetes mellitus
- Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
- Project 11 - Ligand-biased G-protein activation by CaSR
- Project 12 - The role of CaSR in AD pathomechanisms
- Project 13 - In silico analysis of CaSR-ligand interaction
- Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry
Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry
Host Institution: TissueGnostics
» Info
Hypothesis: Pancreatic islands, colon tumours and vascular endothelial cells can be automatically segmented by image cytometry.
Objectives: Automated image cytometry enables identification and quantitative measurement of cell and tissue characteristics (cell number & size, tissue area, cell-cell distances), cellular/sub-cellular localization and quantitative in situ analysis of protein expression in the natural tissue context.
ESRTG will 1) Define (in collaboration with ESRMUW2, ESRUOXF, ESRUL and ESRCU) the cell and tissue structures as well as molecules of interest; and perform standardized sampling, staining and microscope-based processing of relevant tissue samples; 2) Develop and validate of In-Vitro Diagnostics (IVD)-compliant adaptive segmentation algorithms; 3) Apply the algorithms (with ESRMUW2, ESRUOXF, ESRUL and ESRCU) and integrate into the TissueFAXS/StrataQuest workflow.
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