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- Project 1 - CaSR-mediated signalling in colonocytes
- Project 2 - Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer
- Project 3 - Role of the CaSR in inflammatory lung diseases
- Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
- Project 5 - Delineation of CaSR signalling in primary cells and cell lines with native receptor expression
- Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
- Project 7 - Cell-specific CaSR signaling
- Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
- Project 9 - Evaluation of CaSR-targeted drugs for the treatment of diabetes mellitus
- Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
- Project 11 - Ligand-biased G-protein activation by CaSR
- Project 12 - The role of CaSR in AD pathomechanisms
- Project 13 - In silico analysis of CaSR-ligand interaction
- Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry
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Project 13 - In silico analysis of CaSR-ligand interaction
Host Institution: SAFAN
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Hypothesis: CaSR ligands could become therapeutic agents for treating calciotropic disorders such as hyperparathyroidism and non-calciotropic disorders such as cardiovascular disease, diabetes and cancer.
Objectives: Identifying and evaluating the ligand specificity of CaSR receptor modulators. ESRSAFAN will 1) Profile small molecule libraries in silico in close collaboration with the Novartis group. 2) Build a homology model for the CaSR receptor. 3) Evaluate by molecular docking the binding modes of the compounds that result from in silico profiling. 4) Analyse by molecular dynamic simulation techniques the dynamic behaviours of the receptor and of the complexes resulting from molecular docking experiments.
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