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Projects / Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
 
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  • Project 1 - CaSR-mediated signalling in colonocytes
  • Project 2 - Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer
  • Project 3 - Role of the CaSR in inflammatory lung diseases
  • Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
  • Project 5 - Delineation of CaSR signalling in primary cells and cell lines with native receptor expression
  • Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
  • Project 7 - Cell-specific CaSR signaling
  • Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
  • Project 9 - Evaluation of CaSR-targeted drugs for the treatment of diabetes mellitus
  • Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
  • Project 11 - Ligand-biased G-protein activation by CaSR
  • Project 12 - The role of CaSR in AD pathomechanisms
  • Project 13 - In silico analysis of CaSR-ligand interaction
  • Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry


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Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation

Host Institution: Université de Picardie Jules Vernes
» Info

Hypothesis: CaSR is a determinant of osteolytic breast cancer metastases. Activation of the CaSR in breast cancer cells is facilitated by high Ca2+o and /or other molecules which are present in bone microenvironment.

Objectives: ESRUPJV will 1) Investigate the role of CaSR in breast cancer cell migration in vitro, using MDA-MB-231 and MCF-7 breast cancer cells overexpressing the wild-type form of the CaSR or a dominant negative mutant of the receptor. Ca2+o as well as hydroxyapatite will be used as chemoattractant factor. 2) Characterise the role of the CaSR in early bone metastatic event (metastatic stem cells) ex vivo, following bone marrow invasion of zeocin resistant MDA-MB-231 and MCF-7 cells after intracardiac and fat pad injection. 3) Investigate bone targeting potential of chemical modulators of the CaSR in nude mice using MALDI-Mass Spectrometry Imaging after intracardiac injection of breast cancer cell lines.

 
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