Abk�rzung zur Hauptnavigation Abk�rzung zu den Newsmeldungen Abk�rzung zu den Topstories  
  MedUni Vienna    Intranet    MedUni Vienna - Shop    University Library    University Hospital Vienna  
 
casr.png
 
 
 
Hauptnavigation
  • Home
  • General Information
    • Newsletter
    • Outreach
    • Recruitment
    • Meetings
    • Publications
    • Awards
    • Previous Project Multifaceted CaSR
    • Contact
  • Projects
    • Project 1 - CaSR-mediated signalling in colonocytes
    • Project 2 - Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer
    • Project 3 - Role of the CaSR in inflammatory lung diseases
    • Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
    • Project 5 - Delineation of CaSR signalling in primary cells and cell lines with native receptor expression
    • Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
    • Project 7 - Cell-specific CaSR signaling
    • Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
    • Project 9 - Evaluation of CaSR-targeted drugs for the treatment of diabetes mellitus
    • Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
    • Project 11 - Ligand-biased G-protein activation by CaSR
    • Project 12 - The role of CaSR in AD pathomechanisms
    • Project 13 - In silico analysis of CaSR-ligand interaction
    • Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry
  • People
    • ESR Fellows
    • Academic Beneficiaries
    • Non-academic Beneficiaries
    • Partner Organisations
    • Coordination Team
    • Advisory Board
  • Training
    • Secondments
    • E-Learning Modules
    • 1st ETN School: CaSR: Molecular and clinical aspects
    • 2nd ETN School: Translational drug Research
    • 3rd ETN School: Introduction to Academic Teaching
    • 4th ETN School: Self-presentation & Communication
    • 5th ETN School: Research, Innovation Entrepreneurship
 
Projects / Project 1 - CaSR-mediated signalling in colonocytes
 
Subnavigation
  • Project 1 - CaSR-mediated signalling in colonocytes
  • Project 2 - Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer
  • Project 3 - Role of the CaSR in inflammatory lung diseases
  • Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
  • Project 5 - Delineation of CaSR signalling in primary cells and cell lines with native receptor expression
  • Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
  • Project 7 - Cell-specific CaSR signaling
  • Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
  • Project 9 - Evaluation of CaSR-targeted drugs for the treatment of diabetes mellitus
  • Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
  • Project 11 - Ligand-biased G-protein activation by CaSR
  • Project 12 - The role of CaSR in AD pathomechanisms
  • Project 13 - In silico analysis of CaSR-ligand interaction
  • Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry


Inhaltsbereich

Project 1 - CaSR-mediated signalling in colonocytes.

Host Institution: Medical University of Vienna

Hypothesis: The pathways activated by CaSR ligands present in the gut (e.g. aromatic amino acids or polyamines) are distinct from those in other tissues, such as parathyroid.

Objectives: To identify colon-specific signalling pathways driven by the CaSR and to study the consequences of losing CaSR expression in the colon. ESRMUW1 will 1) Examine how “intestine-specific” ligands (L-Phe, poly-Arg or spermine) affect Ca2+-driven CaSR signalling pathways; 2) Test the impact of calcimimetics/calcilytics on the choice of downstream pathways: such as intracellular Ca2+ oscillations, cAMP or IP3 accumulation using the HTRF technology, impact on protein kinase activation by reverse-phase protein array or in-cell western blot;. 3) Study the effect of the New Western Diet (NWD): high in fat low in fibre, folate, calcium and vitamin D on the development of premalignant lesions in mice lacking the CaSR in the intestine.

 
Drucken
 

Quick Links

 
-- News Archive
-- Previous Project Multifaceted CaSR
-- Papers authored by the Multifaceted CaSR Fellows
-- Contact
 
 

Featured

 
 
 
 
 
 
 
© MedUni Wien | Publishing information | Terms of use | Data Protection | Accessibility | Contact