Kate E Lines, Anna K Glück, Supat Thongjuea , Chas Bountra, Rajesh V Thakker, Caroline M Gorvin
The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell lines.
J Mol Endocrinol, 2021 Jul 26;67(3):83-94. doi: 10.1530/JME-21-0030.
https://jme.bioscientifica.com/view/journals/jme/67/3/JME-21-0030.xml
Ana Sastre, Kevin Valentino, Fadil M Hannan, Kate E Lines, Anna K Glück, Mark Stevenson, Michael Ryalls, Rebecca J Gorrigan , Debbie Pullen, Jackie Buck , Sailesh Sankaranarayanan, Jeremy Allgrove, Rajesh V Thakker, Evelien F Gevers.
PTH Infusion for Seizures in Autosomal Dominant Hypocalcemia Type 1. N Engl J Med. 2021 Jul 8;385(2):189-191. doi:10.1056/NEJMc2034981.
https://www.nejm.org/doi/10.1056/NEJMc2034981
Schepelmann M, Kupper N, Sladczyk M, Mansfield B, Manhardt T, Piatek K, Iamartino L, Riccardi D, Kariuki BM, Bassetto M, Kallay E.
Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells. Int J Mol Sci. 2021 Sep 19;22(18):10124. doi: 10.3390/ijms221810124.
https://www.mdpi.com/1422-0067/22/18/10124
Romagnoli C, Sharma P, Zonefrati R, Palmini G, Lucattelli E, Ward DT, Ellinger I, Innocenti M, Brandi ML
Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle. Int J Mol Sci. 2021 Jul 6;22(14):7282. doi: 10.3390/ijms22147282.
https://www.mdpi.com/1422-0067/22/14/7282
Hannan FM, Gorvin CM, Babinsky VN, Olesen MK, Stewart M, Wells S, Cox RD, Nemeth EF, Thakker RV.
Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model. JBMR Plus. 2020; 4(10): e10402. doi: 10.1002/jbm4.10402.
https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbm4.10402
Iamartino L, Elajnaf T, Gall K, David J, Manhardt T, Heffeter P, Grusch M, Derdak S, Baumgartner-Parzer S, Schepelmann M, Kallay E.
Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor
www.sciencedirect.com/science/article/pii/S0167488920301944
Elajnaf T, Iamartino L, Mesteri I, Müller C, Bassetto M, Manhardt T, Baumgartner-Parzer S, Kallay E, Schepelmann M.
Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice. Nutrients. 2019 Dec 16;11(12):3072. doi: 10.3390/nu11123072.
https://www.mdpi.com/2072-6643/11/12/3072
Gorvin CM, Stokes VJ, Boon H, Cranston T, Glück AK, Bahl S, Homfray T, Aung T, Shine B, Lines KE, Hannan FM, Thakker RV.
Activating mutations of the G-protein subunit α11 interdomain interface cause autosomal dominant hypocalcemia type 2,Journal of Clinical Endocrinology and Metabolism, 2020 Mar 1;105(3). pii: dgz251.
doi: 10.1210/clinem/dgz251
https://academic.oup.com/jcem/article/105/3/952/5671666
C. Romagnoli, R. Zonefrati, P. Sharma, M. Innocenti, L. Cianferotti and M.L. Brandi
Characterization of skeletal muscle endocrine control in an in vitro model of myogenesis (2020)
Calcified Tissue International and Musculoskeletal Research
doi: 10.1007/s00223-020-00678-3
https://link.springer.com/article/10.1007/s00223-020-00678-3
P. Dharmaraj, C.M. Gorvin, A. Soni, N.D. Nelhans, M.K. Olesen, H. Boon, T. Cranston, R.V. Thakker, F. M. Hannan
Neonatal Hypocalcemic Seizures in Offspring of a Mother with Familial Hypocalciuric Hypercalcemia Type 1 (FHH1)”, in Journal: J Clin Endocrinol Metab., Publication date: 9th March 2020
doi: 10.1210/clinem/dgaa111
https://academic.oup.com/jcem/article/105/5/dgaa111/5801090
Das S., Clézardin P., Kamel S., Brazier M., Mentaverri R.,
The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases
In: Front. Oncol., 05 February 2020
doi.org/10.3389/fonc.2020.00069
https://www.frontiersin.org/articles/10.3389/fonc.2020.00069/full
I. M Boisen, I. Mos, E. Lerche-Black, A. Juul, H. Bräuner-Osborne, M.B. Jensen
Heterozygous mutation (Q459R) in the calcium-sensing receptor gene causes familial hypocalciuric hypercalcemia 1 (FHH1)”, , (2019) J. Clin. Endorinol. Metab.
doi.org/10.1210/clinem/dgz205
academic.oup.com/jcem/article-abstract/105/4/e1322/5628138
T. Elajnaf, L. Iamartino, I. Mesteri, Ch. Müller, M. Bassetto, T. Manhardt, S. Baumgartner-Parzer, E. Kallay, M. Schepelmann
Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice”, Nutrients, 2019, 11 (12)
DOI: 10.3390/nu11123072
https://www.ncbi.nlm.nih.gov/pubmed/31888253
P.P. Centeno, A. Herberger, H.C. Mun, C. Tu, E.F. Nemeth, W. Chang, A.D. Conigrave, D.T. Ward
Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion Nature Communications. 2019; 10(1),4693
10.1038/s41467-019-12399-9
https://www.nature.com/articles/s41467-019-12399-9
S. Chavez-Abiega, J. Goedhart & F.J. Bruggeman
Physical biology of GPCR signalling dynamics inferred from fluorescence spectroscopy and imaging
Curr Opin Struct Biol. 2019 Apr; 55:204-211.
doi: 10.1016/j.sbi.2019.05.007
https://www.sciencedirect.com/science/article/abs/pii/S0959440X19300296
A Multi-organ Nucleus Segmentation Challenge
Kumar N., ... , Mahbod A., Schaefer G., Ellinger I., Ecker R. , Smedby O., Wang C., et al.
DOI 10.1109/TMI.2019.2947628
https://ieeexplore.ieee.org/document/8880654
Mahbod A., Schaefer G., Ellinger I., Ecker R., Smedby Ö., Wang C.
A Two-Stage U-Net Algorithm for Segmentation of Nuclei in H&E-Stained Tissues.
In: Reyes-Aldasoro C., Janowczyk A., Veta M., Bankhead P., Sirinukunwattana K. (eds) Digital Pathology. ECDP 2019. Lecture Notes in Computer Science, vol 11435. Springer, Cham
https://link.springer.com/chapter/10.1007%2F978-3-030-23937-4_9
Lo Giudice M., Mihalik B., Turia Z., Dinnyes A., Kobolak J.
Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAPP Release from PSEN1 Mutant iPSC-Derived Neurons.
Journal of Alzheimer’s Disease 72 (2019) 885–899
DOI 10.3233/JAD-190602
IOS Press
https://www.ncbi.nlm.nih.gov/pubmed/31640098
García M*, Rodríguez-Hernández CJ*, Mateo-Lozano S*, Pérez-Jaume S, Gonçalves-Alves E, Lavarino C, Mora J, de Torres C.
Parathyroid hormone-like hormone plays a dual role in neuroblastoma depending on PTH1R expression. Mol Oncol. 2019 Jul 10.
doi: 10.1002/1878-0261.12542. [Epub ahead of print]. PMID: 31293052
https://www.ncbi.nlm.nih.gov/pubmed/31293052
Mos I., Jacobsen S.E., Foster S., Brauner-Osborne H.
Calcium-sensing receptor internalization is β-arrestin-dependent and modulated by allosteric ligands. Mol Pharmacol. 2019 Aug 9. pii: mol.119.116772.
doi: 10.1124/mol.119.116772. [Epub ahead of print] PubMed PMID: 31399503.
https://www.ncbi.nlm.nih.gov/pubmed/31399503
Lo Giudice M., Mihalik B., Dinnyés A., Kobolák J.,
The Nervous System Relevance of the Calcium Sensing Receptor in Health and Disease
Published in: Molecules 2019, 24(14), 2546;
doi.org/10.3390/molecules24142546
A.Gluck
The challenges of researching rare genetic diseases.
Published in: The Endocrinologist, Issue 132, Summer 2019
A. Mahbod, G. Schaefer, C. Wang, R. Ecker and I. Ellinger
Skin Lesion Classification Using Hybrid Deep Neural Networks
Published in: ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), Brighton, United Kingdom, 2019, pp. 1229-1233.
DOI: 10.1109/ICASSP.2019.8683352;
https://ieeexplore.ieee.org/abstract/document/8683352
Fusing Fine-tuned Deep Features for Skin Lesion Classification.
Amirreza Mahbod, Gerald Schaefer, Isabella Ellinger, Rupert Ecker, Alain Pitiot, Chunliang Wang
Journal: Computerized Medical Imaging and Graphics. 2018 Nov 03
doi.org/10.1016/j.compmedimag.2018.10.007
Iamartino L, Elajnaf T, Kallay E, Schepelmann M.
World J Gastroenterol. 2018 Sep 28;24(36):4119-4131.
doi: 10.3748/wjg.v24.i36.4119. Review. PMID:30271078
Collection of papers on the role of the physiology and patophysiology of the CaSR
Among the authors: Aggarwal A., Brown E., Conigrave A., Da Torres C., Ellinger I., Kallay E.
Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion. Mahbod, I. Ellinger, R. Ecker, Ö. Smedby, C. Wang.
Springer International Publishing AG, part of Springer Nature 2018 A. Campilho et al. (Eds.): ICIAR 2018, LNCS 10882, pp. 754–762, 2018.
https://doi.org/10.1007/978-3-319-93000-8_85
Ochalek A, Mihalik B, Avci HX, Chandrasekaran A, Téglási A, Bock I, Giudice ML, Táncos Z, Molnár K, László L, Nielsen JE, Holst B, Freude K, Hyttel P, Kobolák J, Dinnyés A.
Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z.
PMID: 29191219
Hannan FM, Olesen MK, Thakker RV.
Br J Pharmacol. 2017 Nov 11. doi: 10.1111/bph.14086. [Epub ahead of print] Review
PMID: 29127708
Skin lesion classification using hybrid deep neural networks
Mahbod A., Ecker R., Ellinger I.
arXiv:1702.08434
Cross Talk between the Calcium-Sensing Receptor and the Vitamin D System in Prevention of Cancer.
Aggarwal A, Kállay E.
Front Physiol. 2016 Oct 18;7:451. Review.
PMID:27803671
The Calcium-Sensing Receptor and the Reproductive System.
Ellinger I.
Front Physiol. 2016 Aug 30;7:371. doi: 10.3389/fphys.2016.00371. Review.
PMID:27625611