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    • Project 1 - CaSR-mediated signalling in colonocytes
    • Project 2 - Evaluation of CaSR - based therapeutics in prevention of tumourigenesis and metastatic potential in colorectal cancer
    • Project 3 - Role of the CaSR in inflammatory lung diseases
    • Project 4 - Evaluation of CaSR-targeted drugs for the treatment of neuroblastoma
    • Project 5 - Delineation of CaSR signalling in primary cells and cell lines with native receptor expression
    • Project 6 - Role of the calcium-sensing receptor (CaSR) in glucose homeostasis
    • Project 7 - Cell-specific CaSR signaling
    • Project 8 - Targeting CaSR in human skeletal muscle cells to delay sarcopenia development
    • Project 9 - Evaluation of CaSR-targeted drugs for the treatment of diabetes mellitus
    • Project 10 - Role of the CaSR in early bone metastasis of breast cancer cells and evaluation of CaSR - based therapeutics in prevention or delay of metastasis formation
    • Project 11 - Ligand-biased G-protein activation by CaSR
    • Project 12 - The role of CaSR in AD pathomechanisms
    • Project 13 - In silico analysis of CaSR-ligand interaction
    • Project 14 -Generation, validation and application of algorithms for tissue segmentation used in advanced tissue cytometry
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    • 1st ETN School: CaSR: Molecular and clinical aspects
    • 2nd ETN School: Translational drug Research
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    • 5th ETN School: Research, Innovation Entrepreneurship
 
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Inhaltsbereich

Publications

2021

 

Kate E Lines, Anna K Glück, Supat Thongjuea , Chas Bountra, Rajesh V Thakker, Caroline M Gorvin

The bromodomain inhibitor JQ1+ reduces calcium-sensing receptor activity in pituitary cell lines.

 

J Mol Endocrinol,  2021 Jul 26;67(3):83-94. doi: 10.1530/JME-21-0030.

 

https://jme.bioscientifica.com/view/journals/jme/67/3/JME-21-0030.xml

 

Ana Sastre, Kevin Valentino, Fadil M Hannan, Kate E Lines, Anna K Glück, Mark Stevenson, Michael Ryalls, Rebecca J Gorrigan , Debbie Pullen, Jackie Buck , Sailesh Sankaranarayanan, Jeremy Allgrove, Rajesh V Thakker, Evelien F Gevers.

PTH Infusion for Seizures in Autosomal Dominant Hypocalcemia Type 1. N Engl J Med. 2021 Jul 8;385(2):189-191. doi:10.1056/NEJMc2034981.

https://www.nejm.org/doi/10.1056/NEJMc2034981

 

Schepelmann M, Kupper N, Sladczyk M, Mansfield B, Manhardt T, Piatek K, Iamartino L, Riccardi D, Kariuki BM, Bassetto M, Kallay E.

Stereo-Specific Modulation of the Extracellular Calcium-Sensing Receptor in Colon Cancer Cells. Int J Mol Sci. 2021 Sep 19;22(18):10124. doi: 10.3390/ijms221810124.

https://www.mdpi.com/1422-0067/22/18/10124

 

Romagnoli C, Sharma P, Zonefrati R, Palmini G, Lucattelli E, Ward DT, Ellinger I, Innocenti M, Brandi ML

Study of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle. Int J Mol Sci. 2021 Jul 6;22(14):7282. doi: 10.3390/ijms22147282.

https://www.mdpi.com/1422-0067/22/14/7282

 

2020

 

Hannan FM, Gorvin CM, Babinsky VN, Olesen MK, Stewart M, Wells S, Cox RD, Nemeth EF, Thakker RV.

Calcilytic NPSP795 Increases Plasma Calcium and PTH in an Autosomal Dominant Hypocalcemia Type 1 Mouse Model. JBMR Plus. 2020; 4(10): e10402. doi: 10.1002/jbm4.10402.

https://asbmr.onlinelibrary.wiley.com/doi/full/10.1002/jbm4.10402

 

Iamartino L, Elajnaf T, Gall K, David J, Manhardt T, Heffeter P, Grusch M, Derdak S, Baumgartner-Parzer S, Schepelmann M, Kallay E.

Effects of pharmacological calcimimetics on colorectal cancer cells over-expressing the human calcium-sensing receptor

www.sciencedirect.com/science/article/pii/S0167488920301944

 

Elajnaf T, Iamartino L, Mesteri I, Müller C, Bassetto M, Manhardt T, Baumgartner-Parzer S, Kallay E, Schepelmann M.

Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice. Nutrients. 2019 Dec 16;11(12):3072. doi: 10.3390/nu11123072.

https://www.mdpi.com/2072-6643/11/12/3072

 

Gorvin CM, Stokes VJ, Boon H, Cranston T, Glück AK, Bahl S, Homfray T, Aung T, Shine B, Lines KE, Hannan FM, Thakker RV.

Activating mutations of the G-protein subunit α11 interdomain interface cause autosomal dominant hypocalcemia type 2,Journal of Clinical Endocrinology and Metabolism, 2020 Mar 1;105(3). pii: dgz251.

doi: 10.1210/clinem/dgz251 

https://academic.oup.com/jcem/article/105/3/952/5671666

 

C. Romagnoli, R. Zonefrati, P. Sharma, M. Innocenti, L. Cianferotti and M.L. Brandi

Characterization of skeletal muscle endocrine control in an in vitro model of myogenesis (2020)

Calcified Tissue International and Musculoskeletal Research

doi: 10.1007/s00223-020-00678-3

https://link.springer.com/article/10.1007/s00223-020-00678-3

 

P. Dharmaraj, C.M. Gorvin, A. Soni, N.D. Nelhans, M.K. Olesen, H. Boon, T. Cranston, R.V. Thakker, F. M. Hannan

Neonatal Hypocalcemic Seizures in Offspring of a Mother with Familial Hypocalciuric Hypercalcemia Type 1 (FHH1)”,  in Journal: J Clin Endocrinol Metab., Publication date: 9th March 2020

doi: 10.1210/clinem/dgaa111

https://academic.oup.com/jcem/article/105/5/dgaa111/5801090 

 

Das S., Clézardin P., Kamel S., Brazier M., Mentaverri R.,

The CaSR in Pathogenesis of Breast Cancer: A New Target for Early Stage Bone Metastases

In: Front. Oncol., 05 February 2020

doi.org/10.3389/fonc.2020.00069

https://www.frontiersin.org/articles/10.3389/fonc.2020.00069/full

 

2019

I. M Boisen, I. Mos, E. Lerche-Black, A. Juul, H. Bräuner-Osborne, M.B. Jensen

Heterozygous mutation (Q459R) in the calcium-sensing receptor gene causes familial hypocalciuric hypercalcemia 1 (FHH1)”, , (2019) J. Clin. Endorinol. Metab.

doi.org/10.1210/clinem/dgz205

academic.oup.com/jcem/article-abstract/105/4/e1322/5628138

 

T. Elajnaf, L. Iamartino, I. Mesteri, Ch. Müller, M. Bassetto, T. Manhardt, S. Baumgartner-Parzer, E. Kallay, M. Schepelmann

Nutritional and Pharmacological Targeting of the Calcium-Sensing Receptor Influences Chemically Induced Colitis in Mice”,  Nutrients, 2019, 11 (12)

DOI: 10.3390/nu11123072

https://www.ncbi.nlm.nih.gov/pubmed/31888253

 

P.P. Centeno, A. Herberger, H.C. Mun, C. Tu, E.F. Nemeth, W. Chang, A.D. Conigrave, D.T. Ward

Phosphate acts directly on the calcium-sensing receptor to stimulate parathyroid hormone secretion Nature Communications. 2019; 10(1),4693
10.1038/s41467-019-12399-9

https://www.nature.com/articles/s41467-019-12399-9

 

S. Chavez-Abiega, J. Goedhart & F.J. Bruggeman

Physical biology of GPCR signalling dynamics inferred from fluorescence spectroscopy and imaging

Curr Opin Struct Biol. 2019 Apr; 55:204-211.

doi: 10.1016/j.sbi.2019.05.007

https://www.sciencedirect.com/science/article/abs/pii/S0959440X19300296

 

A Multi-organ Nucleus Segmentation Challenge

Kumar N., ... , Mahbod A., Schaefer G., Ellinger I., Ecker R. , Smedby O., Wang C., et al.

DOI 10.1109/TMI.2019.2947628

 https://ieeexplore.ieee.org/document/8880654

 

Mahbod A., Schaefer G., Ellinger I., Ecker R., Smedby Ö., Wang C.

A Two-Stage U-Net Algorithm for Segmentation of Nuclei in H&E-Stained Tissues.


In: Reyes-Aldasoro C., Janowczyk A., Veta M., Bankhead P., Sirinukunwattana K. (eds) Digital Pathology. ECDP 2019. Lecture Notes in Computer Science, vol 11435. Springer, Cham

https://link.springer.com/chapter/10.1007%2F978-3-030-23937-4_9

 

Lo Giudice M., Mihalik B., Turia Z., Dinnyes A., Kobolak J.

Calcilytic NPS 2143 Reduces Amyloid Secretion and Increases sAPP Release from PSEN1 Mutant iPSC-Derived Neurons.

Journal of Alzheimer’s Disease 72 (2019) 885–899
DOI 10.3233/JAD-190602
IOS Press

https://www.ncbi.nlm.nih.gov/pubmed/31640098

 

García M*, Rodríguez-Hernández CJ*, Mateo-Lozano S*, Pérez-Jaume S, Gonçalves-Alves E, Lavarino C, Mora J, de Torres C.

Parathyroid hormone-like hormone plays a dual role in neuroblastoma depending on PTH1R expression. Mol Oncol. 2019 Jul 10.

doi: 10.1002/1878-0261.12542. [Epub ahead of print]. PMID: 31293052

https://www.ncbi.nlm.nih.gov/pubmed/31293052

 

Mos I., Jacobsen S.E., Foster S., Brauner-Osborne H.

Calcium-sensing receptor internalization is β-arrestin-dependent and modulated by allosteric ligands. Mol Pharmacol. 2019 Aug 9. pii: mol.119.116772.

doi: 10.1124/mol.119.116772. [Epub ahead of print] PubMed PMID: 31399503.

https://www.ncbi.nlm.nih.gov/pubmed/31399503

 

Lo Giudice M., Mihalik B., Dinnyés A., Kobolák J.,

The Nervous System Relevance of the Calcium Sensing Receptor in Health and Disease

Published in: Molecules 2019, 24(14), 2546;

doi.org/10.3390/molecules24142546

 A.Gluck

The challenges of researching rare genetic diseases.

Published in: The Endocrinologist, Issue 132, Summer 2019

https://www.endocrinology.org/endocrinologist/132-summer-2019/features/the-challenges-of-researching-rare-genetic-diseases/

 

A. Mahbod, G. Schaefer, C. Wang, R. Ecker and I. Ellinger

Skin Lesion Classification Using Hybrid Deep Neural Networks
Published in: ICASSP 2019 - 2019 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), Brighton, United Kingdom, 2019, pp. 1229-1233.
DOI: 10.1109/ICASSP.2019.8683352;
https://ieeexplore.ieee.org/abstract/document/8683352

2018

Fusing Fine-tuned Deep Features for Skin Lesion Classification.

Amirreza Mahbod, Gerald Schaefer, Isabella Ellinger, Rupert Ecker, Alain Pitiot, Chunliang Wang

Journal: Computerized Medical Imaging and Graphics. 2018 Nov 03

doi.org/10.1016/j.compmedimag.2018.10.007

 

Calcium-sensing receptor in colorectal inflammation and cancer: Current insights and future perspectives.

Iamartino L, Elajnaf T, Kallay E, Schepelmann M.

World J Gastroenterol. 2018 Sep 28;24(36):4119-4131.

doi: 10.3748/wjg.v24.i36.4119. Review. PMID:30271078

 

Collection of papers on the role of the physiology and patophysiology of the CaSR

https://www.frontiersin.org/research-topics/4063/physiology-and-pathophysiology-of-the-extracellular-calcium-sensing-receptor

Among the authors: Aggarwal A., Brown E., Conigrave A., Da Torres C., Ellinger I., Kallay E.

 

Breast Cancer Histological Image Classification Using Fine-Tuned Deep Network Fusion. Mahbod, I. Ellinger, R. Ecker, Ö. Smedby, C. Wang. 

Springer International Publishing AG, part of Springer Nature 2018 A. Campilho et al. (Eds.): ICIAR 2018, LNCS 10882, pp. 754–762, 2018.

https://doi.org/10.1007/978-3-319-93000-8_85

 

2017

 

Neurons derived from sporadic Alzheimer's disease iPSCs reveal elevated TAU hyperphosphorylation, increased amyloid levels, and GSK3B activation

Ochalek A, Mihalik B, Avci HX, Chandrasekaran A, Téglási A, Bock I, Giudice ML, Táncos Z, Molnár K, László L, Nielsen JE, Holst B, Freude K, Hyttel P, Kobolák J, Dinnyés A.

Alzheimers Res Ther. 2017 Dec 1;9(1):90. doi: 10.1186/s13195-017-0317-z.

PMID: 29191219

 

Calcimimetic and calcilytic therapies for inherited disorders of the calcium-sensing receptor signalling pathway

Hannan FM, Olesen MK, Thakker RV.

Br J Pharmacol. 2017 Nov 11. doi: 10.1111/bph.14086. [Epub ahead of print] Review

PMID: 29127708

 

Skin lesion classification using hybrid deep neural networks

Mahbod A., Ecker R., Ellinger I.

arXiv:1702.08434

2016

Cross Talk between the Calcium-Sensing Receptor and the Vitamin D System in Prevention of Cancer.

Aggarwal A, Kállay E.

Front Physiol. 2016 Oct 18;7:451. Review.

PMID:27803671 

 

The Calcium-Sensing Receptor and the Reproductive System.

Ellinger I.

Front Physiol. 2016 Aug 30;7:371. doi: 10.3389/fphys.2016.00371. Review.

PMID:27625611 


 
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